Figure 1
From: Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice
DAex, 5-HTex, and NEex in the striatum in DD mice. (a) METH-induced elevation of DAex levels in DD mice at 24 h after the last L-DOPA injection. ***P<0.001, compared with saline (SAL) group of the same genotype (two-way ANOVA followed by Fisher’s protected least significant difference (PLSD) post hoc test). (b) METH-induced elevation of DAex levels in DD mice at 72 h after the last L-DOPA injection. Baseline DAex could not be detected in DD mice. One-way ANOVA revealed a significant effect of drug (F1, 9=27.2431, P<0.001). ***P<0.001; NA, not applicable. (c) METH-induced elevation of 5-HTex levels in DD mice at 72 h after the last L-DOPA injection. ***P<0.001, compared with saline group within the same genotype (two-way ANOVA followed by Fisher’s PLSD post hoc test). (d) METH-induced elevation of NEex levels in DD mice at 72 h after the last L-DOPA injection. **P<0.01, compared with saline group within the same genotype (two-way ANOVA followed by Fisher’s PLSD post hoc test). The figure shows the time course of DAex, 5-HTex, or NEex before and after a subcutaneous injection of saline (SAL) or METH (1 mg/kg). The arrow indicates the drug injection time. Each point represents the mean±SEM of the percentage of baseline DAex, 5-HTex, or NEex. The histogram represents the mean AUC±SEM of DAex,5- HTex, or NEex during the 180 min period after the saline or METH injection (n=4–7).
