Figure 2
From: Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice
Locomotor activity and gait features in DD mice. (a) Locomotor activity in DD mice at 24 or 72 h after the last L-DOPA injection (n=10–29). The arrow indicates the saline injection time. *P<0.05, **P<0.01, ***P<0.001, compared with wild-type mice (Student’s t-test). The data are expressed as mean±SEM. (b) Interjoint coordination patterns during the step cycle period in wild-type mice (n=8) and DD mice (n=9). The angle–angle plots illustrate the averaged data for coordination between joints of the hindlimb. (A) Knee vs hip. (B) Ankle vs knee. (C) Ankle vs hip. White star, foot contact at the beginning of the stance phase. Gray star, foot lift at the beginning of the swing phase. (c) Range of angular joint excursions during the step cycle period in wild-type mice (n=8) and DD mice (n=9). (A) Hip. (B) Knee. (C) Ankle. The data are expressed as mean±SEM. **P<0.01, ***P<0.001, compared with wild-type mice (Student’s t-test). (d, e) Temporal and spatial parameters of stride length (d) and walking speed (e) in wild-type mice (n=8) and DD mice (n=9) during locomotion. The data are expressed as mean±SEM. **P<0.01, ***P<0.001, compared with wild-type mice (Student’s t-test).
