Figure 2 | Neuropsychopharmacology

Figure 2

From: Loss of Feedback Inhibition via D2 Autoreceptors Enhances Acquisition of Cocaine Taking and Reactivity to Drug-Paired Cues

Figure 2

Augmented DA transients after cocaine in mice lacking D2 autoreceptors. (a) Representative oDA transients before (black) and after cocaine (10 μM, red) in control, autoDrd2KO, and control mice in the presence of sulpiride. (b) Decay time constant (τ) of oDA transients before (black) and after cocaine (red) in control (open), autoDrd2KO (solid), and control mice in the presence of sulpiride (shaded). (c) Amplitude of oDA transients after cocaine expressed as percentage of baseline for control (open), autoDrd2KO mice (solid), and control mice in sulpiride (shaded). All data expressed as mean±SEM.

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