Figure 1
From: Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone
In the two-bottle choice paradigm, D3−/− mice show a lower voluntary ethanol intake as compared with wild-type (WT). D3 pharmacological antagonism inhibits ethanol intake in WT mice. (a, b) Voluntary ethanol intake was measured every 24 h, for 44 days, in WT (n=30) and D3−/− (n=30) mice that had free access to water and ethanol solution (10%). (c) Shows total fluid intake that was not different in the two groups. (d, e), Voluntary ethanol intake was measured as in a, but in mice that had received the day before and kept receiving daily i.p. injection of either saline (vehicle, VEH, n=10), U99194A (n=10) or SB277011A (n=10), either drug at 10 mg/kg. (f) Total fluid intake in either group that was not affected by drug treatment. ***p<0.001 vs water or vehicle (VEH). One-way ANOVA and Newman–Keuls post hoc test.
