Figure 6
From: Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone
DA receptor signaling is enhanced in striatum of D3R−/− mice and of SB277011A-treated WT mice. The abundance of phosphorylated DARPP-32 (Thr 34) (a) and phosphorylated GSK3β (Ser 9) (b) was assessed by immunoblot, in the striatum of WT mice exposed to the long-term voluntary ethanol intake (white columns) and injected i.p. for 14 days with either vehicle or 10 mg/kg SB277011A and in D3−/− (black columns). Brain tissues were taken 1 h after the last administration of either vehicle or SB277011A. Bar graphs show mean (± SEM) of intensities normalized against the respective non-phosphorylated protein. Each column is the mean (± SEM) from five different samples. *p<0.05 vs control (vehicle-injected WT). Two-way ANOVA and Newman–Keuls post hoc test.
