Figure 2
Effect of microRNA 137 (MIR137) rs1625579 genotype on dorsolateral prefrontal cortex-hippocampal formation (DLPFC-HF) functional connectivity and working memory performance. (a) DLPFC functional connectivity analyses using the right DLPFC (seed voxel MNI coordinate: x=42, y=33, z=33) as the seed region revealed a increased DLPFC connectivity with the left HF (peak voxel MNI coordinate: x=−27, y=−12, z=−18) in the homozygotes for the risk allele (TT) compared with TG individuals (family-wise error (FWE) corrected p<0.05). (b) Independent region-of-interest (ROI) analyses by taking the structural HF as ROI further supported that DLPFC-HF functional connectivity was different between the two different genotype groups (mean±SD). (c) Individual DLPFC-HF connectivity negatively correlated with individual working memory performance in TG individuals (right red scatter diagram), whereas the correlation did not exist in TT individuals (left blue scatter diagram).
