Figure 3
Transcription factor binding sites and biological processes enriched in cocaine-responsive genes. (a) Binding sites for the transcription factors GATA, AP-1, and STAT3 were significantly enriched in genes with robust differential expression in cocaine abusers (Table 2) compared with all human genes (fold-enrichment and P-values indicated). (b) Cocaine-responsive genes (Table 2) hierarchically cluster into a small number of broad groups significantly enriched for distinct biological processes. Clusters A, B and C-D-E encompass upregulated genes, while cluster F encompasses all downregulated genes; r indicates correlation coefficients. More detailed hierarchical clustering and GO term enrichment data are provided in Supplementary Figure 2 and Supplementary Table 2, respectively. TFBS, transcription factor binding site.
