Abstract
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.
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Acknowledgements
KM’s work is funded by NIH Grants R01 MH093332, R01 MH079299, R01 MH067234, and P30 HD015052. MJS’ work was partially supported by a Vanderbilt Brain Institute Scholar Award.
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Schmidt, M., Mirnics, K. Neurodevelopment, GABA System Dysfunction, and Schizophrenia. Neuropsychopharmacol 40, 190–206 (2015). https://doi.org/10.1038/npp.2014.95
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DOI: https://doi.org/10.1038/npp.2014.95
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