Table 3 Analysis of mRNA Expression of DMR-Associated Genes

Gene	THC-associated expression change	% of VEH mean (THC)	±SEM (THC)	P -value ^c	DMR state	DMR location
Dlg4 ^a	Upregulated	113	0.045	0.044	NA	NA
Dlgap2 ^a	Upregulated	115	0.038	0.015	Hyper	Gene body; intron
Kcna5 ^a	Upregulated	121	0.06	0.017	Hyper	Promoter region; exon
Begain ^a	Upregulated	113	0.049	0.044	Hyper	Gene body; exon
Grin2a ^a	Downregulated	76	0.086	0.049	Hypo	Gene body; exon
Dlgap3 ^a	NS	112	0.06	0.136	Hyper	Gene body; exon
Scn5a ^a	NS	85	0.069	0.136	Hypo	Gene body; intron
Grik5 ^a	NS	108	0.037	0.179	Hypo	Gene body; intron
Kcnj10 ^a	NS	106	0.027	0.208	Hypo	Gene body; exon
Shank1 ^a	NS	94	0.058	0.522	Hyper	Gene body; exon
Mta1 ^b	NS	121	0.042	0.057	Hyper	Gene body; intron
Cdh15 ^b	NS	110	0.039	0.164	Hyper	Gene body; exon
Ntrk2 ^b	NS	105	0.028	0.338	Hypo	Gene body; intron

Abbreviations: DMR, differentially methylated region; NS, non-significant; NA, not applicable; THC, tetrahydrocannabinol; VEH, control vehicle.
^aGene is part of the Dlg4 interaction network shown in Figure 5.
^bGene is overlapped by top DMR shown in Table 1.
^cWelch two-sample t-test.

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