Figure 1 | Neuropsychopharmacology

Figure 1

From: Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice

Figure 1

Inducible ablation of GLT1 in adolescent mice. (a) Generation of adolescent-GLASTCreERT2/+/GLT1flox/flox mice (iKO) or control (Ctrl) mice by tamoxifen (Tmx) or oil injections. (b) Western blot analysis of GLT1 of the cerebral cortex, thalamus and striatum from postnatal day (P) 63 mice (n=3). Monomer bands of GLT1, or β-Actin are shown. GLT1 band intensities were normalized with those of β-actin. All data are presented as the mean±SEM. Student’s t-tests were used to compare GLT1 protein levels of Ctrl and iKO mice for each brain region. *P<0.05, ***P<0.005. (c) GLT1 immunohistochemistry. Boxed regions were enlarged in the right panels. Scale bar: 1 mm, and 100 μm for inset. (d) Facial lesions in 12- to 16-week-old male iKO mice.

PowerPoint slide

Back to article page