Figure 3
Increased seizure severity in iKO mice. (a) Seizure severity was tested in 8-week-old-Ctrl and iKO mice (n=8 and 12, respectively) by intraperitoneal administration of 30 mg/kg kainic acid. Higher maximum seizure scores represent more severe seizure status; a score of 7 indicates mortality. Statistical significance was calculated by Mann–Whitney’s u-test. **P<0.01. (b) EEG recordings from iKO mice (n=4). A representative EEG trace from somatosensory cortex is shown (upper panel). Lines represent periods of grooming bouts. Arrows indicate timing of tic-like movements. EEG traces around grooming onsets are enlarged in lower panels. Lines with gray boxes represent periods of grooming bouts. iKO mice do not show any epileptiform discharge both during resting states and grooming bouts.
