Figure 2
From: Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids
Fluoxetine amplifies endocannabinoid (eCB)-mediated suppression of inhibitory amygdala transmission. Cartoon depiction of recordings of inhibitory transmission in the basolateral amygdala (BLA), with example traces showing effects of the CB1 receptor (CB1R) antagonist, SR141716 (SR) (a). Application of SR141716 increased inhibitory postsynaptic potential (IPSP) amplitude after chronic fluoxetine, unmasking eCB-mediated suppression of inhibitory transmission (b, c). Depolarization-induced suppression of inhibition was unaltered after chronic fluoxetine treatment (scale bars: 100 pA, 10-ms, stimulation artifacts deleted from traces for clarity) (d, e). Data are means±SEM. *P<0.01. eIPSC, evoked inhibitory postsynaptic current; Flx, fluoxetine; GABA, γ-aminobutyric acid; Wtr, water.
