Figure 3
From: Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids
Fluoxetine (Flx) facilitates extinction through CB1 receptor (CB1R) signaling in the amygdala. Chronic fluoxetine treatment following conditioning and before extinction reduced freezing on extinction retrieval in a manner prevented by pre-extinction administration of the CB1R antagonist, SR141716 (SR) (a). Chronic fluoxetine after conditioning and before extinction reduced freezing on extinction retrieval in a manner prevented by pre-extinction bilateral microinfusion of the CB1R antagonist, SR141716, into the basolateral amygdala (BLA) (b). Pre-extinction administration of the fatty acid amide hydrolase (FAAH) inhibitor, AM3506, reduced freezing on extinction retrieval (c). Chronic fluoxetine treatment or administration of the FAAH inhibitor, AM3506, before extinction reduced freezing on extinction retrieval in a non-additive manner (d). Data are means±SEM. *P<0.05. AM, AM3506; Con, conditioning; Ext, extinction; Flx, fluoxetine; Ret, retrieval; Wtr, water.
