Figure 2
Adult PDE11A knockout (KO) mice show deficits in long-term memory (LTM) for social odor recognition (SOR) but not nonsocial odor recognition (NSOR). (a) A diagram of the SOR and NSOR paradigms are shown, where ‘memory’ is operationally defined as spending significantly more time investigating the novel vs the familiar odor. (b) PDE11A wild-type (WT) and knockout (KO) mice exhibit significant short-term memory (STM) for SOR 1 h after training. (c) In contrast to their WT littermates, PDE11A KO mice exhibit absolutely no LTM for SOR 24 h after training. (d) This LTM deficit appears to be selective for social odors because PDE11A KO mice demonstrate robust NSOR memory 24 h after training, and this memory is equally as strong as that shown by their WT littermates. (b), n=32–38/genotype; (c), n=18–21/genotype; (d), n=29–31/genotype. Post hoc, *vs familiar and home-cage odors, P<0.001; vs #WT within odor, P<0.03–0.001.
