Figure 3
Adult PDE11A knockout (KO) mice show normal short-term memory (STM) for social transmission of food preference (STFP) but no long-term memory (LTM). (a) A diagram of the STFP assay is shown, where memory is operationally defined as mice demonstrating a significant preference for the trained vs novel food. Both PDE11A wild-type (WT) and KO mice show normal STM for STFP 10 min after training, whether measuring preference in terms of (b) the amount of each food eaten or (c) the time spent eating the trained vs novel food. In contrast, PDE11A KO mice show no LTM for STFP 24 h after training whether measuring preference in terms of (d) the amount of each food or (e) the time spent eating the trained vs novel. (b and c), n=28–34/genotype; (d and e), n=24/genotype. Post hoc, *trained vs novel, P<0.001; #WT vs KO within novel or trained, P⩽0.002–0.001.
