Table 1 Values and Statistics for the Subjective and Cardiovascular Peak Effects
From: LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality
Placebo 100 μg (mean±SE) | LSD 100 μg (mean±SE) | Placebo 200 μg (mean±SE) | LSD 200 μg (mean±SE) | Drug | Drug × Dose | |||
|---|---|---|---|---|---|---|---|---|
F1,38= | p= | F1,38= | p= | |||||
Subjective effects | ||||||||
Visual Analog Scales (VAS, %) | ||||||||
Any drug effect | 0.9±0.6 | 87.5±3.3*** | 0.1±0.1 | 97.2±1.7***# | 1939 | *** | 6.21 | * |
Good drug effect | 0.9±0.6 | 85.2±3.4*** | 0.1±0.1 | 96.8±1.5***## | 1661 | *** | 7.66 | ** |
Bad drug effect | 0.0±0.0 | 17.3±3.6** | 0.1±0.06 | 40.0±8.2***### | 51.17 | *** | 8.01 | ** |
Fear | 0.0±0.0 | 8.4±2.3 | 0.06±0.1 | 31.3±8.6***### | 27.74 | *** | 9.24 | ** |
Happy | 1.2±0.6 | 30±3.4*** | 5.0±2.0 | 39.1±4.2*** | 141.5 | *** | 1 | NS |
Closeness to others | 0.0±0.0 | 15.2±3.2*** | 4.3±1.8 | 32.3±4.7***### | 61.68 | *** | 5.38 | * |
Open | 0.2±0.2 | 17.0±2.8*** | 3.9±1.5 | 41.0±3.6***### | 128.9 | *** | 18.4 | *** |
Trust | 0.0±0.0 | 22.0±4.1*** | 4.8±2.1 | 39.8±4.0***### | 81.37 | *** | 4.2 | * |
I want to be hugged | 0.0±0.0 | 8.8±2.7 | 3.4±1.9 | 27.8±6.8***### | 23.52 | *** | 5.13 | * |
I want to hug someone | 0.0±0.0 | 10.4±2.7* | −1.4±3.3 | 27.6±6.1***## | 41.21 | *** | 9.13 | ** |
I want to be alone | 0.6±0.6 | 7.7±2.5 | 5.1±1.9 | 17.6±5.6 | 9.93 | ** | 0.76 | NS |
I want to be with other people | 0.8±0.8 | 12.8±2.5** | 10.8±4.2 | 42.8±5.5***### | 79.87 | *** | 16.25 | *** |
Adjective Mood Rating Scale (AMRS, Δ score) | ||||||||
Well-being | 0.0±0.6 | 2.5±1.0 | 1.8±0.7 | 6.6±1.6* | 11.49 | ** | 1.11 | NS |
Emotional excitation | −0.3±0.2 | 2.3±0.5** | −0.3±0.3 | 4.7±1.0***## | 53.5 | *** | 4.77 | * |
Inactivity | 2.6±0.7 | 9.0±1.1** | 1.3±1.1 | 10.6±2.7*** | 30.82 | *** | 1.05 | NS |
Extroversion | −0.5±0.3 | −0.1±0.6 | 0.1±0.5 | 1.5±0.7 | 2.67 | NS | 0.77 | NS |
Introversion | 0.4±0.1 | 4.1±0.6*** | 0.5±0.4 | 4.3±0.8*** | 51.92 | *** | 0.01 | NS |
Fear | −0.1±0.1 | 0.9±0.3 | −0.4±0.3 | 1.3±1.0 | 9.51 | ** | 0.72 | NS |
Dreaminess | 0.2±0.3 | 6.9±0.7*** | 0.8±0.5 | 7.9±0.6*** | 160.2 | *** | 0.11 | NS |
Vital signs | ||||||||
Systolic blood pressure (mm Hg) | 129±2.0 | 142±2.1*** | 133±3.8 | 148±2.9*** | 63.8 | *** | 0.13 | NS |
Diastolic blood pressure (mm Hg) | 76.9±1.5 | 85.7±1.7*** | 78.2±2.0 | 87.6±1.9*** | 68.8 | *** | 0.08 | NS |
Heart rate (beats/min) | 70.6±1.8 | 79.1±2.7** | 72.8±2.6 | 86.9±4.29*** | 33.7 | *** | 2.05 | NS |
Body temperature (Δ°C) | 0.5±0.1 | 0.8±0.1** | 0.3±0.1 | 0.7±0.1** | 23.74 | *** | 0.22 | NS |
Pupil size (mm) | 6.1±0.2 | 6.9±0.1*** | 6.5±0.2 | 7.2±0.1*** | 61.08 | *** | 0.81 | NS |
Pupil size after light (mm) | 4.3±0.2 | 5.2±0.2*** | 4.6±0.2 | 5.6±0.2*** | 89.61 | *** | 0.02 | NS |
List of complaints (Δ LC total score) | ||||||||
Acute adverse effects (0–10 h) | 0.5±0.3 | 9.8±1.8*** | 0.1±0.6 | 10.4±3.0*** | 38.37 | *** | 0 | NS |
Subacute adverse effects (10–24 h) | −0.2±0.3 | 0.4±0.2 | −0.4±0.4 | 3.7±1.4** | 12.06 | ** | 6.76 | * |
Subacute adverse effects (24–72 h) | −0.5±0.3 | −0.1±0.2 | −0.8±0.4 | 0.6±0.9 | 6.03 | * | 1.83 | NS |
