Figure 4
Adolescent and adult CUS induces depression-like phenotype in mice in adulthood. (a) A main effect of sex (*P<0.05) and a trend toward a decrease in latency to first bout of immobility due to a main effect of stress (^P=0.0596) was found in male and female mice exposed to adolescent stress (S) and tested in the FST in adulthood compared with no stress controls (NS). Bars represent latency in seconds to first bout of immobility±SEM. Sample sizes are indicated on the figure. (b) Male and female adult mice exposed to adolescent CUS spend more time immobile in the FST compared with nonstressed control male and female mice (**P<0.001). A main effect of sex influenced time spent immobile in the FST in male and female mice (#P<0.05). Bars represent time spent immobile in seconds over 6 consecutive min±SEM. (c) Exposure to adult CUS decreases latency to first bout of immobility in male and female mice compared with nonstress controls (***P<0.0001). (d) Male and female adult mice exposed to adult CUS spend more time immobile over the 6 min FST compared with nonstressed controls (***P<0.0001).
