Figure 2
Nicotine potentiated medial prefrontal cortex (mPFC) gamma oscillations and locomotion upon daily exposures. (a) mPFC oscillatory activity throughout nicotine sessions. Each image is the average of Z-scored spectrograms from individual rats (color bar: Z-scored power). (b) From top to bottom, the graphs compare high-gamma, low-gamma, and theta–beta oscillations, either between days 1 and 5 (left) or between day 1 and the late session (right). Shaded curves represent ±SEM, and Tukey’s significant effects between days are indicated above each panel (comparing 3 min bins). (c) Comparison of movement counts either between days 1 and 5 (top) or day 1 and the late session (bottom). (d) Scatter plots correlating averaged data from the first 15 min after nicotine administration. Top: movement count vs low gamma power in the third session. Bottom: movement count vs high gamma power in the fifth session. Each point represents a rat. Pearson’s R statistics showing significant correlations are also displayed.
