Figure 2
From: CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity
Schematic view of the mtCB1-dependent signaling pathway. CB1 receptors are present in brain mitochondria likely in the external membrane where they regulate the respiratory chain and ultimately the mitochondrial functions (eg, ATP production). On the right, we represented the signaling pathway downstream mtCB1 receptors. It has been described that mtCB1 receptors mediate its effects involving intra-mitochondrial Gi/o protein signaling, mitochondrial cAMP synthesis that is catalyzed by a soluble form of adenylyl cyclase (sAC), and the decrease of intra-mitochondrial PKA activity that also reduced phosphorylation of specific subunits of complex I (eg, NDUFS2). All these events can impair the respiratory chain decreasing mitochondrial respiration, likely affecting other mitochondria functions. For additional information refer to the main text.
