Figure 3
From: Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus
No typical schizophrenia-related phenotypes in mutant mice. (a) No difference was detected between the genotypes in the pre-pulse inhibition of the startle reflex (F(1,51)=0.9, p=0.34), and (b) no differences in the startle reflex magnitude (F(1,51)=1.2, p=0.27). (c) There were no differences in the % alternation in the spatial Y-maze working memory task (t(22)=−0.30, p=0.76). (d) MK-801 (0.3 mg/kg, i.p.) showed an increase in the horizontal activities (# beam cross) in the open field. No difference in altered responsiveness to MK-801 (F(1,49)=2.6, p=0.11). (e) Amphetamine (2.5 mg/kg, i.p.) showed an increase in the horizontal activities (# beam cross) in the open field. No difference between the genotypes in the horizontal activities before (repeated measures ANOVA, F(1,132)=1.49, p=0.14) and after the drug treatment (repeated measures ANOVA, F(1,276)=0.30, p=0.99). (f) No difference between the genotypes in the baseline dopamine levels in NAC lateral shell (t(11)=0.48, p=0.65) before the amphetamine treatment. No difference between the genotypes in amphetamine (Amph)-induced dopamine increase in NAC lateral shell (repeated measures ANOVA, F(1,44)=0.10, p=0.98). Data are mean±SEM; animal number n is indicated in parentheses or plot bars.
