Table 1 Localization of Changes in Brain Activity After 8-week Antidepressant Treatment and During Resting State Correlated with Peripheral miR-1202 Levels

From: Co-Variation of Peripheral Levels of miR-1202 and Brain Activity and Connectivity During Antidepressant Treatment

Cluster size

 

Peak voxel (MNI)

BA

Side

Region

 

Z

x

y

Z

   

Within default mode network

 Correlation with T0 miR-1202

—

       

 Correlation with T8/T0 miR-1202

78

−4.1

40

−74

38

19/39

R

Precuneus

Functional connectivity with posterior cingulate cortex

 Correlation with T0 miR-1202

139

−5.5

30

−94

−4

18

R

Middle and inferior occipital gyrus

59

−5.7

36

14

52

6/8

R

Middle and superior frontal gyrus

59

−6.4

−48

−36

60

40

L

Inferior parietal lobe/post-central gyrus

50

−7.5

34

58

16

10

R

Middle and superior frontal gyrus

47

−7.5

−40

54

16

10

L

Middle and superior frontal gyrus

43

−8.9

16

−86

10

17/18

R

Occipital cortex/Cuneus

43

−8.4

−34

44

38

9

L

Superior and middle frontal gyrus

 Correlation with T8/T0 miR-1202

61

−4.1

−60

−6

−14

21

L

Middle temporal gyrus

56

−6.1

10

48

16

10

R

Middle frontal gyrus

38

−6.6

−6

−66

32

7/31

L

Precuneus

  1. Abbreviations: BA, Brodmann Area; L, left; MNI, Montreal Neurological Institute coordinates; R, right; T0, levels at baseline; T8, levels after 8 week antidepressant treatment.
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