Figure 2
From: Dysfunction of Microglial STAT3 Alleviates Depressive Behavior via Neuron–Microglia Interactions
Loss of microglial signal transducer and activator of transcription 3 (STAT3) leads to antidepressive-like behavior. (a) Under control or chronic restraint stress conditions, immobility time of the wild-type (WT) and knockout (KO) mice was assessed by tail suspension test (Control; 148.943±9.943 s vs 103.537±13.837 s, n=12 and 11, Stress; 198.208±8.490 s vs 124.013±13.878 s in the WT and KO mice, n=9 and 10, respectively). (b) Under control or chronic restraint stress conditions, immobility time of the WT and KO mice was assessed by forced swim test (Control; 115.945±9.695 s vs 65.678±10.593 s, n=10 and 11, Stress; 197.328±9.733 s vs 131.727±16.008 s in the WT and KO mice, n=9 and 10, respectively). (c) Preference for sucrose under control or chronic restraint stress conditions (Control; 75.776±1.914% vs 77.061±1.943%, Stress; 55.13±4.146% vs 75.833±2.341% in the WT and KO mice, n=10 and 9, respectively). (d) Total liquid intake under control or chronic restraint stress conditions (Control; 4.91±0.119 ml vs 4.95±0.092 ml, Stress; 5.24±0.121 ml vs 5.1±0.097 ml in the WT and KO mice, n=10 and 9, respectively). (e) Total distance (11794.746±811.651 cm vs 9267.810±819.674 cm in the WT and KO mice) and (f) time spent in the center of the open field (160.3±19.6 s vs 168.9±34 s in the WT and KO mice, n=8 and 9, respectively). (g) Time spent in the open arms of plus arms (133.6±17.5 s vs 150.4±30.2 s in the WT and KO mice, n=8 and 9, respectively). (h) Total running time on the rotating drum (n=8 and 9, respectively). Data are means±SEM, *p<0.05, **p<0.01, and ***p<0.001 compared with WT; #p<0.05, ##p<0.01, and ###p<0.001 compared with control.
