Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

Nature Precedings
  • View all journals
  • Search
  • My Account Login
  • Content Explore content
  • About the journal
  • RSS feed
  1. nature
  2. nature precedings
  3. articles
  4. article
Are plants with anti-cancer activity resistant to crown gall? : A test of hypothesis
Download PDF
Download PDF
  • Manuscript
  • Open access
  • Published: 28 December 2007

Are plants with anti-cancer activity resistant to crown gall? : A test of hypothesis

  • R Srirama1,
  • BT. Ramesha2,
  • G. Ravikanth3,
  • R. Uma Shaanker2 &
  • …
  • KN Ganeshaiah4 

Nature Precedings (2007)Cite this article

  • 854 Accesses

  • 3 Citations

  • Metrics details

Abstract

The Crown gall tumour assay (CGTA) is one of several bench top bioassays recommended for the rapid screening of plants with anti-cancer activity. The rationale for the use of the bioassay is that the tumorogenic mechanism initiated in plant tissues by Agrobacterium tumefaciens is in many ways similar to that of animals. Several plant species with anti-cancer activity have already been discovered using this bioassay. However till date no explicit test of an association between anti-cancer activity of plants and their resistance to crown gall formation has been demonstrated. Demonstration of an association could have exploratory potential when searching for plants with anti-cancer activity. In this paper, we determined whether or not a statistically significant association between crown gall resistance and anti-cancer activity exists in plants found in existing published data sets. Our results indicate that plants with anti-cancer activity have a higher proportion of their species resistant to crown gall formation compared to a random selection of plants. We discuss the implications of our results especially when prospecting for newer sources of anti-cancer activity in plants.

Similar content being viewed by others

Determination of optimum extract conditions and evaluation of biological activity potential of Salvia cilicica Boiss

Article Open access 18 March 2025

Systems identification and characterization of β-glucuronosyltransferase genes involved in arabinogalactan-protein biosynthesis in plant genomes

Article Open access 25 November 2020

Integrated transcriptome and metabolomics analyses revealed key functional genes in Canna indica under Cr stress

Article Open access 18 June 2024

Article PDF

Author information

Authors and Affiliations

  1. School of Ecology and Conservation, University of Agricultural Sciences, Bangalore, 560 065, India

    R Srirama

  2. Department of Crop Physiology, School of Ecology and Conservation, University of Agricultural Sciences, Bangalore, 560 065, India

    BT. Ramesha & R. Uma Shaanker

  3. Ashoka Trust for Research in Ecology and Environment, Hebbal, Bangalore

    G. Ravikanth

  4. Department of Genetics and Plant Breeding, School of Ecology and Conservation, University of Agricultural Sciences, Bangalore, 560 065, India

    KN Ganeshaiah

Authors
  1. R Srirama
    View author publications

    Search author on:PubMed Google Scholar

  2. BT. Ramesha
    View author publications

    Search author on:PubMed Google Scholar

  3. G. Ravikanth
    View author publications

    Search author on:PubMed Google Scholar

  4. R. Uma Shaanker
    View author publications

    Search author on:PubMed Google Scholar

  5. KN Ganeshaiah
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to R. Uma Shaanker.

Rights and permissions

Creative Commons Attribution 3.0 License.

Reprints and permissions

About this article

Cite this article

Srirama, R., Ramesha, B., Ravikanth, G. et al. Are plants with anti-cancer activity resistant to crown gall? : A test of hypothesis. Nat Prec (2007). https://doi.org/10.1038/npre.2007.1456.1

Download citation

  • Received: 22 December 2007

  • Accepted: 28 December 2007

  • Published: 28 December 2007

  • DOI: https://doi.org/10.1038/npre.2007.1456.1

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Keywords

  • anti-cancer activity
  • crown gall resistance
  • NCI
Download PDF

Advertisement

Explore content

  • Research articles
  • News & Comment
  • Sign up for alerts
  • RSS feed

About the journal

  • Journal Information

Search

Advanced search

Quick links

  • Explore articles by subject
  • Find a job
  • Guide to authors
  • Editorial policies

Nature Precedings (Nat Preced)

nature.com sitemap

About Nature Portfolio

  • About us
  • Press releases
  • Press office
  • Contact us

Discover content

  • Journals A-Z
  • Articles by subject
  • protocols.io
  • Nature Index

Publishing policies

  • Nature portfolio policies
  • Open access

Author & Researcher services

  • Reprints & permissions
  • Research data
  • Language editing
  • Scientific editing
  • Nature Masterclasses
  • Research Solutions

Libraries & institutions

  • Librarian service & tools
  • Librarian portal
  • Open research
  • Recommend to library

Advertising & partnerships

  • Advertising
  • Partnerships & Services
  • Media kits
  • Branded content

Professional development

  • Nature Awards
  • Nature Careers
  • Nature Conferences

Regional websites

  • Nature Africa
  • Nature China
  • Nature India
  • Nature Japan
  • Nature Middle East
  • Privacy Policy
  • Use of cookies
  • Legal notice
  • Accessibility statement
  • Terms & Conditions
  • Your US state privacy rights
Springer Nature

© 2025 Springer Nature Limited

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing