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Extracting Functional Modules from Biological Pathways
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  • Published: 27 December 2007

Extracting Functional Modules from Biological Pathways

  • Sihai Zhao1 &
  • Yong Li1 

Nature Precedings (2007)Cite this article

  • 367 Accesses

  • 2 Citations

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Abstract

It has been proposed that functional modules are the fundamental units of cellular function. Methods to identify these modules have thus far relied on gene expression data or protein-protein interaction (PPI) data, but have a few limitations. We propose a new method, using biological pathway data to identify functional modules, that can potentially overcome these limitations. We also construct a network of these modules using functionally relevant PPI data. This network displays the flow and integration of information between modules and can be used to map cellular function.

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Authors and Affiliations

  1. Molecular Discovery Informatics, GlaxoSmithKline R&D, 709 Swedeland Road, UMW2230, King of Prussia, PA, 19406

    Sihai Zhao & Yong Li

Authors
  1. Sihai Zhao
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  2. Yong Li
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Corresponding authors

Correspondence to Sihai Zhao or Yong Li.

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Cite this article

Zhao, S., Li, Y. Extracting Functional Modules from Biological Pathways. Nat Prec (2007). https://doi.org/10.1038/npre.2007.1457.1

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  • Received: 22 December 2007

  • Accepted: 27 December 2007

  • Published: 27 December 2007

  • DOI: https://doi.org/10.1038/npre.2007.1457.1

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Keywords

  • biological pathways
  • Functional modules
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