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Requirement of Activation for Hepatitis B Virus Infection
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  • Published: 25 June 2007

Requirement of Activation for Hepatitis B Virus Infection

  • Michael Bruns1 &
  • Claudia Maenz2 

Nature Precedings (2007)Cite this article

  • 425 Accesses

  • 1 Citations

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Abstract

Although _in vitro_ models of human hepatitis B virus replication are established, so far none could approximate infection efficiency as expected from in vivo observations. Susceptibility for HBV infections has only been reported for primary hepatocytes of human, chimpanzee or Tupaia belangeri and the cell line HepaRG. Here we show that the insusceptible human hepatoma cell line HepG2 can be infected, when the virus was beforehand activated by passage over whole duck liver cell cultures. That suggests an activation step to be performed by specialized liver cells.

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Authors and Affiliations

  1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg https://www.nature.com/nature

    Michael Bruns

  2. Institut für Tumorbiologie https://www.nature.com/nature

    Claudia Maenz

Authors
  1. Michael Bruns
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  2. Claudia Maenz
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Bruns, M., Maenz, C. Requirement of Activation for Hepatitis B Virus Infection. Nat Prec (2007). https://doi.org/10.1038/npre.2007.221.1

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  • Received: 25 June 2007

  • Accepted: 25 June 2007

  • Published: 25 June 2007

  • DOI: https://doi.org/10.1038/npre.2007.221.1

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