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A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters
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  • Published: 23 July 2008

A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters

  • Nathalie Bruck1,
  • Dominique Vitoux2,
  • Christine Ferry1,
  • Vanessa Duong1,
  • Annie Bauer1,
  • Hughes de The3 &
  • …
  • Cecile Rochette-Egly1 

Nature Precedings (2008)Cite this article

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Abstract

The nuclear retinoic acid (RA) receptor alpha (RAR&x03B1;) is a transcriptional transregulator that controls the expression of specific gene subsets through binding at response elements and dynamic interactions with coregulators, which are coordinated by the ligand. Here, we highlighted a novel paradigm in which the transcription of RAR&x03B1;-target genes is controlled by phosphorylation cascades initiated by the rapid RA activation of the p38MAPK/MSK1 pathway. We demonstrate that MSK1 phosphorylates RAR&x03B1; at S369 located in the Ligand Binding Domain, allowing the binding of TFIIH and thereby phosphorylation of the N-terminal domain at S77 by cdk7/cyclin H. MSK1 also phosphorylates Histone H3 at S10. Finally, the phosphorylation cascade initiated by MSK1 is required for the recruitment of RAR&x03B1;/TFIIH complexes to response elements and subsequently for RAR&x03B1; target genes activation. Cancer cells characterized by a deregulated p38MAPK/MSK1 pathway, do not respond to RA, outlining the essential contribution of the RA-triggered phosphorylation cascade in RA signaling.

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Authors and Affiliations

  1. IGBMC, Functional genomics, Strasbourg, France

    Nathalie Bruck, Christine Ferry, Vanessa Duong, Annie Bauer & Cecile Rochette-Egly

  2. CNRS UMR 7151, Hopital saint Louis, Paris, France

    Dominique Vitoux

  3. CNRS UMR 7151, Centre Hayem, Paris, France

    Hughes de The

Authors
  1. Nathalie Bruck
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  2. Dominique Vitoux
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  3. Christine Ferry
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  4. Vanessa Duong
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  5. Annie Bauer
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  6. Hughes de The
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  7. Cecile Rochette-Egly
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Corresponding author

Correspondence to Cecile Rochette-Egly.

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Bruck, N., Vitoux, D., Ferry, C. et al. A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters. Nat Prec (2008). https://doi.org/10.1038/npre.2008.2107.1

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  • Received: 22 July 2008

  • Accepted: 23 July 2008

  • Published: 23 July 2008

  • DOI: https://doi.org/10.1038/npre.2008.2107.1

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Keywords

  • transcription
  • Retinoic acid receptors
  • MSK1
  • phosphorylation
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