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Far-infrared rays control prostate cancer cells in vitro and in vivo
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  • Published: 20 March 2009

Far-infrared rays control prostate cancer cells in vitro and in vivo

  • Hiroki Shima1,
  • Shingo Yamamoto1,
  • Jun Qiu1,
  • Mayumi Shincho2,
  • Seiichi Hirota2,
  • Yoshie Yoshikawa3,
  • Reigetsu Yoshikawa3 &
  • …
  • Tomoko Hashimoto-Tamaoki3 

Nature Precedings (2009)Cite this article

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Abstract

We introduce a new effective method to control hormone refractory prostate cancer cells by using an activated rubber/resin form (RB), far-infrared ray emitter, with or without sodium butyrate (SB). The growth of three human prostate cancer cell lines (Du145, PC-3 and LNCaP) was suppressed in vitro and in vivo by using RB, and the cells were eradicated with RB + 3 mM SB. G1 arrest and apoptotic pathway proteins were induced by RB with intensified expressions of apoptosis - related mRNA on cDNA microarray. RB radiates far-infrared rays of the 4 to 25 [mu]m wavelengths to an object which exert a favorable influence on a cancer control. These results may render us a new therapeutic modality in hormone refractory prostate cancer.

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Authors and Affiliations

  1. Department of Urology, Hyogo College of Medicine https://www.nature.com/nature

    Hiroki Shima, Shingo Yamamoto & Jun Qiu

  2. Department of Surgical Pathology, Hyogo College of Medicine https://www.nature.com/nature

    Mayumi Shincho & Seiichi Hirota

  3. Department of Genetics, Hyogo College of Medicine https://www.nature.com/nature

    Yoshie Yoshikawa, Reigetsu Yoshikawa & Tomoko Hashimoto-Tamaoki

Authors
  1. Hiroki Shima
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  2. Shingo Yamamoto
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  3. Jun Qiu
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  4. Mayumi Shincho
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  5. Seiichi Hirota
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  6. Yoshie Yoshikawa
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  7. Reigetsu Yoshikawa
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  8. Tomoko Hashimoto-Tamaoki
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Corresponding author

Correspondence to Hiroki Shima.

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Cite this article

Shima, H., Yamamoto, S., Qiu, J. et al. Far-infrared rays control prostate cancer cells in vitro and in vivo. Nat Prec (2009). https://doi.org/10.1038/npre.2009.1980.2

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  • Received: 20 March 2009

  • Accepted: 20 March 2009

  • Published: 20 March 2009

  • DOI: https://doi.org/10.1038/npre.2009.1980.2

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Keywords

  • far-infrared rays
  • cancer
  • prostate cancer
  • microarray
  • apoptosis
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