Abstract
It is the first report that the earlier Alzheimer's pathological changes can be induced in normal C57BL mice, by B6 deficient feeding for 3 month, and this pathological changes were completely inhibited by anti-homocysteic acid antibody. According to Koch's postulate, if a pathogen of Alzheimer's disease is administrated to the normal animal, we would observe the Alzheimer's pathology in the normal animal. We actually have observed this pathology in normal C57BL male mice.
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Hasegawa, T., Mikoda, N., Kitazawa, M. et al. B6 deficient feeding or homocysteic acid induces the earlier Alzheimer's pathological change in normal C57BL male mice. Nat Prec (2009). https://doi.org/10.1038/npre.2009.2764.1
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DOI: https://doi.org/10.1038/npre.2009.2764.1
