Homocysteic acid as a pathogen for Alzheimer's disease

Abstract

It has been considered that Alzheimer’s disease may be induced by multi-pathogenic factors. However recent Nature Genetics has reported that sporadic Alzheimer’s disease is also genetically determined by such as ApoE4, Clusterin, so on. We already understand familiar Alzheimer’s disease is determined by such APP, Presenilin genes. These reports should allow us to consider that these genes stimulate the biological process and consequently Alzheimer’s disease would be determined by certain pathogen. Then what is the pathogen? First this pathogen should be stimulated by certain biological process by these genetic activation, which I mean that these genes separately work to induce this pathogen. I really propose that homocysteic acid (HA) is this pathogen. Now I am clarifying why HA is the pathogen from these genes’ stimulation.