Abstract
Objective:
To evaluate the mechanism of action of Krishnavajrabhraka Bhasma(KVB) in chronic asthma.
Methodology:
30 animals divided into 5 groups: 1)vehicle(water) 2)vehicle(honey) 3)Low dose KVB 4)High dose KVB 5)Standard drug.Expt I:- Mast cell stabilization-On day 1, animals were sensitized with egg albumin. Treatment started from day 22 in two ways: a)Single dose b)14days. Egg albumin challenge was given at the end of the treatment. Rats were sacrificed, mesentery collected & observed for mast cell degranulation.Expt II:- Anti-inflammatory action-Croton oil was injected in the back in all rats to make a pouch. After 7 days of drug treatment, animals were sacrificed, pouch removed & weighed. Exudate was measured.
Results:
Expt.I – KVB was found to have mast cell stabilizing action in both experiments. High dose of KVB was equally effective as sodium-cromoglycate.Expt.II – High dose of KVB showed significant reduction of inflammation comparable to diclofenac.
Conclusion:
KVB has mast cell stabilizing & anti-inflammatory activity.
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Sarda, K., Pandit, V., Dawane, J. et al. Study Mechanism Of Action Of Krishnavajrabhraka Bhasma In Asthma. Nat Prec (2010). https://doi.org/10.1038/npre.2010.5422.1
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DOI: https://doi.org/10.1038/npre.2010.5422.1
