Can Plant-Made Copper Chaperones Heal Early Alzheimer’s Disease?

Abstract

Therapeutic recombinant plant-made copper chaperone for superoxide dismutase (CCS) derived from Ginkgo biloba leaves may establish and maintain physiologic Cu levels through restoration and modulation of biometal metabolism in organ systems of younger Alzheimer patients (> 50 years). Medications developed from plant-made copper chaperone proteins may delay progression during early disease stages or even be a basis for a possible causal treatment of preclinical stages of Alzheimer’s disease by restoring cellular function of the CCS-SOD-1 mechanism and by preventing formation of Aβ plaques, a major putative factor involved in Alzheimer’s disease pathogenesis.