Abstract
Introduction:Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find a new capacity for this drug rather than symptomatic effect.
Materials and Methods:
A chronic rotenone model with daily oral dose of 30mg/kg was induced in mice. Pramipexole was tried in a new approach where the treatment began in the middle of rotenone course with oral dose 1mg/kg/day of pramipexole.
Results:
Further analysis of behavioral tests and immunohistochemistry revealed success of pramipexole in improving the rotenone intoxicated mice.
Conclusion:
These results showed possible beneficial effects of pramipexole against rotenone-induced neurotoxicity.
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Gad-Elhak, S., Salama, M., El-Tantawy, D. et al. Pramipexole protective effect on rotenone induced neurotoxicity in mice . Nat Prec (2011). https://doi.org/10.1038/npre.2011.6640.1
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DOI: https://doi.org/10.1038/npre.2011.6640.1
