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Prevention

B vitamins and CVD—failure to find a simple solution

Nature Reviews Cardiology volume 7, pages 608–609 (2010)Cite this article

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The hope that a simple, affordable, and safe homocysteine-lowering intervention with folic acid and vitamin B12 would improve outcomes for patients with established cardiovascular or renal disease has been crushed by the null results from large B-vitamin treatment trials completed to date.

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References

  1. Joseph, J., Handy, D. E. & Loscalzo, J. Quo vadis: whither homocysteine research? Cardiovasc. Toxicol. 9, 53–63 (2009).

    Article  CAS  Google Scholar 

  2. Humphrey, L. L., Fu, R., Rogers, K., Freeman, M. & Helfand, M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin. Proc. 83, 1203–1212 (2008).

    Article  Google Scholar 

  3. Armitage, J. M. et al. for the SEARCH Collaborative Group. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA 303, 2486–2494 (2010).

    Article  CAS  Google Scholar 

  4. Clarke, R. et al. for the B-Vitamin Treatment Trialists' Collaboration. Effects of homocysteine-lowering with B-vitamins on cardiovascular disease, cancer and cause-specific mortality: meta-analysis of 8 randomized trials involving 37,485 individuals (in press).

  5. Cole, B. F. et al. for the Polyp Prevention Study Group. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297, 2351–2359 (2007).

    Article  CAS  Google Scholar 

  6. Ebbing, M. et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12 . JAMA 302, 2119–2126 (2009).

    Article  CAS  Google Scholar 

  7. Hustad, S. et al. The methylenetetrahydrofolate reductase 677C T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am. J. Hum. Genet. 80, 846–855 (2007).

    Article  CAS  Google Scholar 

  8. Lichtenstein, A. H. & Russell, R. M. Essential nutrients: food or supplements? Where should the emphasis be? JAMA 294, 351–358 (2005).

    Article  CAS  Google Scholar 

  9. Refsum, H. et al. The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J. Nutr. 136, 1731S–1740S (2006).

    Article  CAS  Google Scholar 

  10. Ebbing, M. et al. Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J. Intern. Med. doi: 10.1111/j.1365–27962010.02259.x.

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Author information

Authors and Affiliations

  1. Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, 5021, Bergen, Norway

    Marta Ebbing

  2. Section for Pharmacology, Institute of Medicine, University of Bergen, 9th floor, New Laboratory Building, 5021, Bergen, Norway

    Per Magne Ueland

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  1. Marta Ebbing
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  2. Per Magne Ueland
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Correspondence to Marta Ebbing.

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Competing interests

P. M. Ueland is a member of the steering board of the nonprofit Foundation to Promote Research into Functional Vitamin B12 Deficiency, and Bevital AS, a company owned by the foundation. M. Ebbing declares no competing interests.

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Ebbing, M., Ueland, P. B vitamins and CVD—failure to find a simple solution. Nat Rev Cardiol 7, 608–609 (2010). https://doi.org/10.1038/nrcardio.2010.138

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