Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Pharmacogenetics

Ticagrelor superior to clopidogrel in individuals predicted to be clopidogrel responders

Nature Reviews Cardiology volume 8, page 4 (2011)Cite this article

Subjects

A new study has assessed the effect of genotype on platelet function in patients who received ticagrelor or clopidogrel in two multicenter, randomized, double-blind, double-dummy, phase II clinical trials—ONSET/OFFSET and RESPOND. Ticagrelor was found to be a more-efficacious antiplatelet agent than clopidogrel, even in those individuals predicted to be clopidgrel responders on the basis of genotype.

Clopidogrel is often used in combination with aspirin in the treatment of patients with acute coronary syndromes. However, the efficacy of clopidogrel varies widely and response to this drug is known to be influenced by single-nucleotide polymorphisms of the cytochrome P450 isoenzymes, which convert clopidogrel to its active metabolite, and of a transmembrane transporter P-glycoprotein gene, ABCB1. Alternative P2Y12-receptor inhibitors have, therefore, been sought.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Tantry, U. S. et al. First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies. Circ. Cardiovasc. Genet. doi:10.1161/CIRCGENETICS.110.958561

    CAS  Google Scholar 

Download references

Authors
  1. Bryony M. Mearns
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mearns, B. Ticagrelor superior to clopidogrel in individuals predicted to be clopidogrel responders. Nat Rev Cardiol 8, 4 (2011). https://doi.org/10.1038/nrcardio.2010.195

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrcardio.2010.195

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing