Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Risk factors

Severe psoriasis linked with increased cardiovascular mortality

Nature Reviews Cardiology volume 7, page 118 (2010)Cite this article

Subjects

Access through your institution
Buy or subscribe

At least 2–4% of the adult population have psoriasis, a T-helper (TH)1/17-mediated inflammatory disease of the skin and joints. Factors secreted from these TH cells are also involved in the pathogenesis of various cardiovascular conditions. Indeed, epidemiological studies have shown an independent association between psoriasis and atherosclerosis, coronary artery disease, myocardial infarction, stroke, endothelial dysfunction, and diabetes. A cohort study by Nehal Mehta and colleagues has now demonstrated that patients with severe psoriasis are at increased risk of death from cardiovascular disease.

...the increased risk associated with severe psoriasis was greater than that associated with other more-traditional cardiovascular risk factors...

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Mehta, N. N. et al. Patients with severe psoriasis are at risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur. Heart J. doi: 10.1093/eurheart/ehp567

Download references

Authors
  1. Bryony M. Mearns
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mearns, B. Severe psoriasis linked with increased cardiovascular mortality. Nat Rev Cardiol 7, 118 (2010). https://doi.org/10.1038/nrcardio.2010.6

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nrcardio.2010.6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing