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Coronary artery disease

New troponin T test allows prediction of CV events in patients with stable CAD

Nature Reviews Cardiology volume 7, page 120 (2010)Cite this article

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The current lower limit for detection of plasma troponin T in most commercially available tests is approximately 0.01 μg/l, and levels higher than this value are associated with increased mortality. However, even small elevations in cardiac troponins are linked to recurrent coronary ischemic events in patients with suspected acute coronary syndromes. According to Dr Torbjørn Omland from the Akershus University Hospital in Norway, “using conventional assays, the prevalence of detectable troponin T levels in the general population is less than 1%, suggesting that conventional assays are unlikely to provide prognostic information in low-risk populations.

Roche Diagnostics has developed a highly sensitive troponin T assay that can detect levels as low as 0.001 μg/l. Omland states that “when [the PEACE trial investigators] learned that a prototype of a new, highly sensitive troponin T assay had been developed, we hypothesized that troponin T measured with the new assay would be detectable in a high proportion of patients with stable coronary artery disease (CAD) and be associated with the incidence of cardiovascular events.” They have now demonstrated that this new assay can be used to distinguish between patients with stable CAD who are at high risk of having future cardiovascular events and those who are at low risk.

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ORIGINAL RESEARCH PAPERS

  1. Omland, T. et al. A sensitive cardiac troponin T assay in stable coronary artery disease. N. Engl. J. Med. 361, 2538–2547 (2009)

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  1. Bryony M. Mearns
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Mearns, B. New troponin T test allows prediction of CV events in patients with stable CAD. Nat Rev Cardiol 7, 120 (2010). https://doi.org/10.1038/nrcardio.2010.9

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  • DOI: https://doi.org/10.1038/nrcardio.2010.9

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