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Transplantation

A noninvasive strategy to monitor rejection in patients with a heart transplant

Nature Reviews Cardiology volume 7, page 418 (2010)Cite this article

Subjects

The IMAGE investigators randomly assigned 602 patients who had undergone cardiac transplantation at least 6 months previously to the AlloMap® Molecular Expression test (XDx, Brisbane, CA, USA), or endomyocardial biopsies. The composite primary outcome of the study was first occurrence of rejection with hemodynamic compromise, graft dysfunction resulting from other causes, death, or retransplantation.

Median follow-up was 19 months. As expected, patients monitored with gene-expression profiling underwent fewer biopsies during follow-up than patients in the biopsy group (0.5 versus 3 per patient-year). Gene-expression profiling was not associated with an increased risk of serious adverse outcomes. The gene-profiling and biopsy groups had similar 2-year cumulative rates of the composite primary outcome (14.5% and 15.3%, respectively) and death (6.3% and 5.5%, respectively).

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ORIGINAL RESEARCH PAPER

  1. Pham, M. X. et al. Gene-expression profiling for rejection surveillance after cardiac transplantation. N. Engl. J. Med. 362, 1890–1900 (2010)

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Authors
  1. Helene Myrvang
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Myrvang, H. A noninvasive strategy to monitor rejection in patients with a heart transplant. Nat Rev Cardiol 7, 418 (2010). https://doi.org/10.1038/nrcardio.2010.94

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  • DOI: https://doi.org/10.1038/nrcardio.2010.94

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