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Device therapy

Treating restenosis after drug-eluting stent implantation

Nature Reviews Cardiology volume 10, page 62 (2013)Cite this article

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The investigators enrolled 402 patients with restenosis after implantation of a limus-eluting stent and randomly assigned them to receive a PES (n = 131), PEB (n = 137), or balloon angioplasty with no drug elution (n = 134). Paclitaxel was used in both drug-eluting devices to restrict differences to the device itself. PES and PEB were superior to angioplasty with a noneluting balloon, as measured by the diameter of stenosis 6–8 months after treatment (37.4%, 38.0%, and 54.1% respectively). PEB was noninferior to PES.

Target lesion revascularization 1 year after the procedure occurred less frequently in patients treated with PES or PEB than in patients who had angioplasty with a noneluting balloon (13.5%, 22.1%, and 43.5% respectively). The differences between PES and PEB were not statistically significant. All groups had comparable rates of death, myocardial infarction and target lesion thrombosis.

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ORIGINAL RESEARCH PAPER

  1. Byrne, R. A. et al. Paclitaxel-eluting balloons, paclitaxel-eluting stents, and balloon angioplasty in patients with restenosis after implantation of a drug-eluting stent (ISAR-DESIRE 3): a randomised, open-label trial. Lancet doi:10.1016/S0140-6736(12)61964-3

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  1. Megan Cully
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Cully, M. Treating restenosis after drug-eluting stent implantation. Nat Rev Cardiol 10, 62 (2013). https://doi.org/10.1038/nrcardio.2012.189

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