Remote ischaemic conditioning has been extensively studied, and encouraging proof-of-concept clinical trial data have emerged. A study newly published in The Lancet takes the field an important step forward, demonstrating for the first time that remote ischaemic conditioning before CABG surgery reduces all-cause mortality.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Feasibility of prehospital delivery of remote ischemic conditioning by emergency medical services in chest pain patients: protocol for a pilot study
Pilot and Feasibility Studies Open Access 13 March 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout

References
Thielmann, M. et al. Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial. Lancet 382, 597–604 (2013).
Heusch, G. Cardioprotection: chances and challenges of its translation to the clinic. Lancet 381, 166–175 (2013).
Davidson, S. M. et al. Remote ischaemic preconditioning involves signalling through the SDF-1α/CXCR4 signalling axis. Basic Res. Cardiol. 108, 377 (2013).
Mastitskaya, S. et al. Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones. Cardiovasc. Res. 95, 487–494 (2012).
Murry, C. E., Jennings, R. B. & Reimer, K. A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74, 1124–1136 (1986).
Yellon, D. M. & Downey, J. M. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol. Rev. 83, 1113–1151 (2003).
Zhao, Z. Q. et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am. J. Physiol. Heart Circ. Physiol. 285, H579–H588 (2003).
Przyklenk, K., Bauer, B., Ovize, M., Kloner, R. A. & Whittaker, P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 87, 893–899 (1993).
Domanski, M. J. et al. Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery. JAMA 305, 585–591 (2011).
Venugopal, V., Laing, C. M., Ludman, A., Yellon, D. M. & Hausenloy, D. Effect of remote ischemic preconditioning on acute kidney injury in nondiabetic patients undergoing coronary artery bypass graft surgery: a secondary analysis of 2 small randomized trials. Am. J. Kidney Dis. 56, 1043–1049 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Bell, R., Yellon, D. Remote ischaemic conditioning—approaching prime time?. Nat Rev Cardiol 10, 619–621 (2013). https://doi.org/10.1038/nrcardio.2013.154
Published:
Issue date:
DOI: https://doi.org/10.1038/nrcardio.2013.154
This article is cited by
-
Feasibility of prehospital delivery of remote ischemic conditioning by emergency medical services in chest pain patients: protocol for a pilot study
Pilot and Feasibility Studies (2019)