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Pharmacogenetics

HCRTR2 gene is associated with response to HF therapy

Nature Reviews Cardiology volume 13, page 64 (2016)Cite this article

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“The current study by Perez et al. used GWAS [genome-wide association study] to identify a new gene variant candidate that is strongly associated with altering the response to conventional HF [heart failure] therapy, which could lead to novel drug treatments,” explain Walter J. Koch and Alessandro Cannavo in an editorial that accompanies a new study published in JACC.

“Some patients dramatically respond to HF therapy with large increases in ejection fraction (EF) associated with positive remodelling of the left ventricle, whereas others deteriorate,” the investigators observe in their report. The researchers studied response to therapy in 866 patients with clinically diagnosed HF. The responses were categorized, and 'dramatic responders' — patients at the extreme of the distribution of dynamic change — were genotyped to inform the design of a customized microarray to identify single nucleotide variants associated with response to HF therapy. A further 798 patients were recruited for an independent replication study to validate results.

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References

  1. Perez, M. V. et al. Systems genomics identifies a key role for hypocretin/orexin receptor-2 in human heart failure. J. Am. Coll. Cardiol. 66, 2522–2533 (2015)

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  1. Clarissa Oeser
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Oeser, C. HCRTR2 gene is associated with response to HF therapy. Nat Rev Cardiol 13, 64 (2016). https://doi.org/10.1038/nrcardio.2015.195

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