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Acute coronary syndromes

Risk of acute MI with NSAID use

Nature Reviews Cardiology volume 14, page 384 (2017)Cite this article

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Oral nonsteroidal anti-inflammatory drug (NSAID) use is associated with an increased risk of acute myocardial infarction (MI) according to a meta-analysis published in the BMJ. “Risk was greatest during the first month of NSAID use and with higher doses,” report the researchers.

The Bayesian meta-analysis of individual patient data included 446,763 individuals from Canada and Europe, 61,460 of whom had an MI. The drugs studied were the traditional NSAIDs diclofenac, ibuprofen, and naproxen, and the cyclooxygenase 2-selective NSAIDs celecoxib and rofecoxib.

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References

  1. Bally, M. et al. Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data. BMJ 357, j1909 (2017)

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  1. Gregory B. Lim
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González-Gay, M. A. & González-Juanatey, C. Inflammtion: NSAIDs and cardiovascular risk in arthritis. Nat. Rev. Cardiol. 14, 69–70 (2017)

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Lim, G. Risk of acute MI with NSAID use. Nat Rev Cardiol 14, 384 (2017). https://doi.org/10.1038/nrcardio.2017.83

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