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Visceral adipose tissue regulates cardiac ageing

Nature Reviews Cardiology volume 15, page 255 (2018)Cite this article

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Osteopontin (OPN) is a matricellular protein that is upregulated in models of pathological cardiac fibrosis and remodelling. OPN plasma levels also increase with age, and a new study published in Circulation reveals that OPN secreted by visceral adipose tissue (VAT) promotes age-associated interstitial fibrosis in the heart.

VAT drives cardiac ageing by releasing profibrotic factors such as OPN

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References

  1. Sawaki, D. et al. Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production. Circulation https://doi.org/10.1161/CIRCULATIONAHA.117.031358 (2018)

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  1. Alexandra Le Bras
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Hassan, M. et al. Adipose tissue: friend or foe? Nat. Rev. Cardiol. 9, 689–702 (2012)

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Le Bras, A. Visceral adipose tissue regulates cardiac ageing. Nat Rev Cardiol 15, 255 (2018). https://doi.org/10.1038/nrcardio.2018.29

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  • DOI: https://doi.org/10.1038/nrcardio.2018.29

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