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Immunotherapy

A promising vaccine for glioblastoma multiforme

Nature Reviews Clinical Oncology volume 8, page 4 (2011)Cite this article

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A vaccine that targets EGFR variant III (EGFRvIII) can improve survival in patients with newly diagnosed glioblastoma multiforme, Sampson and colleagues report. The vaccine induces mutation-specific immunity in patients with EGFRvIII-positive glioblastoma multiforme and may be linked to the eradication of cells expressing EGFRvIII at disease recurrence.

Preclinical data have indicated that an EGFRvIII-targeted vaccine has activity in glioblastoma multiforme. These findings formed the basis for the latest investigation by Sampson and coworkers. The researchers assessed 35 patients with EGFRvIII-positive glioblastoma multiforme treated with radiation therapy and temozolomide, 18 of whom also received the vaccine.

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ORIGINAL RESEARCH PAPER

  1. Sampson, J. H. et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J. Clin. Oncol. 28, 4722–4729 (2010)

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  1. Lisa Richards
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Richards, L. A promising vaccine for glioblastoma multiforme. Nat Rev Clin Oncol 8, 4 (2011). https://doi.org/10.1038/nrclinonc.2010.201

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