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Breast cancer

Stable breast cancer xenograft models

Nature Reviews Clinical Oncology volume 10, page 426 (2013)Cite this article

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A new study has demonstrated stable, transplantable, xenograft models that are biologically consistent with the breast tumours of origin.

A factor that hinders breast cancer research is the limited number of in vivo models that accurately reflect the heterogeneity of human tumours. In vivo therapeutic studies often use xenograft models in which human cancer cell lines are transplanted into mice. However, these cell lines have been shown to evolve in culture, acquiring genomic changes not present in the original tumour.

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ORIGINAL RESEARCH PAPER

  1. Zhang, X. et al. A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenografts. Cancer Res. doi:10.1158/0008-5472.CAN-12-4081

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Authors
  1. Vanessa Marchesi
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Marchesi, V. Stable breast cancer xenograft models. Nat Rev Clin Oncol 10, 426 (2013). https://doi.org/10.1038/nrclinonc.2013.111

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  • DOI: https://doi.org/10.1038/nrclinonc.2013.111

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