Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Haematological cancer

ALL classification—integration of genomic and cytogenetic data

Nature Reviews Clinical Oncology volume 11, page 440 (2014)Cite this article

Subjects

Acute lymphoblastic leukaemia (ALL) is characterized by several chromosomal abnormalities that have an important diagnostic and prognostic value, and by numerous genomic copy number alterations with a yet unknown clinical relevance. Anthony Moorman and colleagues have integrated these genomic data with cytogenetic data to refine the genetic classification of paediatric B-cell precursor ALL.

The researchers used a multiplex PCR-based technique to determine the copy number of eight commonly altered genes (IKZF1, CDKN2A/B, PAX5, EBF1, ETV6, BTG1, and RB1) in more than 1,500 patients. “The integration of genomic data in an established cytogenetic classification enabled the identification of two genetic risk groups with different outcome”, explains Moorman. The good-risk genetic group included 75% of children who had excellent response to standard therapy, with a predicted 5-year event free survival and overall survival of 94% and 97%, and who could be considered for reduced treatment. The second group included 25% of children with a poor-risk genetic profile, who would benefit from intensive treatment.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Moorman, A. V. et al. A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia (ALL). Blood 10.1182/blood-2014-03-562918

Download references

Authors
  1. Alessia Errico
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Errico, A. ALL classification—integration of genomic and cytogenetic data. Nat Rev Clin Oncol 11, 440 (2014). https://doi.org/10.1038/nrclinonc.2014.117

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrclinonc.2014.117

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer