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Breast cancer

PALB2—a new player in hereditary breast cancer

Nature Reviews Clinical Oncology volume 11, page 560 (2014)Cite this article

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Loss-of-function mutations in PALB2 are associated with an increased risk of breast cancer; however, the lifetime risk of this disease for women who have inherited PALB2 mutations is not known. Marc Tischkowitz and colleagues have now shown that the risk of breast cancer for PALB2 mutation carriers can be as high as the risk reported for BRCA2 carriers.

The investigators collected data on 362 individuals with PALB2 mutations from 154 eligible families, and used a modified segregation-analysis approach to determine the age-specific risk of breast cancer, considering the effects of PALB2 genotype and residual familial aggregation.

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References

  1. Antoniou, A. C. et al. Breast-cancer risk in families with mutations in PALB2. N. Engl. J. Med. 10.1056/NEJMoa1400382

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Authors
  1. Alessia Errico
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Errico, A. PALB2—a new player in hereditary breast cancer. Nat Rev Clin Oncol 11, 560 (2014). https://doi.org/10.1038/nrclinonc.2014.142

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  • DOI: https://doi.org/10.1038/nrclinonc.2014.142

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