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Lung cancer

Heterogeneity in space and time

Nature Reviews Clinical Oncology volume 11, page 684 (2014)Cite this article

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Lung cancer is the leading cause of cancer-related mortality worldwide. Understanding the pathogenesis and evolution of this disease might guide therapy and improve prognosis. Two articles published in Science elucidate the high level of intratumour heterogeneity (ITH) in lung cancer.

In the first study, Zhang et al. sequenced the DNA from 48 regions of 11 lung cancers and reported that 76% of mutations were present in all regions of the same tumour, but the number and type of mutations varied substantially among tumours.

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References

  1. de Bruin, E. C. et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 10.1126/science.1253462

  2. Zhang, J. et al. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science 10.1126/science.1256930

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Authors
  1. Alessia Errico
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Errico, A. Heterogeneity in space and time. Nat Rev Clin Oncol 11, 684 (2014). https://doi.org/10.1038/nrclinonc.2014.186

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  • DOI: https://doi.org/10.1038/nrclinonc.2014.186

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