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Genetics

The Cancer Genome Atlas maps papillary thyroid cancer

Nature Reviews Clinical Oncology volume 11, page 681 (2014)Cite this article

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The most-common form of thyroid cancer is papillary thyroid carcinoma (PTC), the incidence of which is increasing. Although PTC generally has a good prognosis, with 5-year survival often exceeding 95%, some cases dedifferentiate into more-aggressive tumours. The Cancer Genome Atlas (TCGA) Research Network have turned their attention to this disease, and have published new data that improve our understanding of the biology of PTC.

The TCGA researchers used their multiplatform 'omics' methodology, comprising next-generation DNA and RNA sequencing, copy-number analysis, and transcriptomic, methylomic and proteomic assays, to comprehensively characterize 496 PTCs at the molecular level. These data were combined with clinicopathological data to correlate the molecular findings with factors such as histopathological subtype, and risk of recurrence and mortality. Clinically aggressive tumours were excluded to focus on the categorization of driver mutations.

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References

  1. The Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma. Cell 159, 676–690 (2014)

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Authors
  1. David Killock
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Killock, D. The Cancer Genome Atlas maps papillary thyroid cancer. Nat Rev Clin Oncol 11, 681 (2014). https://doi.org/10.1038/nrclinonc.2014.193

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