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Prevention

Daily aspirin and chemoprevention

Nature Reviews Clinical Oncology volume 11, page 180 (2014)Cite this article

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The regular use of aspirin has been associated with a reduced risk of cancer, particularly of the gastrointestinal tract. Two recent studies have consolidated the role of aspirin as a chemopreventive drug.

In the first study, Trabert and colleagues evaluated the effect of the use of aspirin, nonaspirin NSAIDs and acetaminophen on ovarian cancer by pooling data from 12 population-based case-control studies. Trabert explains that “women who reported daily aspirin use had a 20% lower risk of ovarian cancer compared with women who did not take aspirin regularly.” This effect was most prominent among women receiving a low-dose aspirin regimen, similar to the one used for cardiovascular protection. As Trabert reinforces, “future studies are needed to evaluate the benefits and harms of taking aspirin for ovarian cancer prevention,” and to justify the use of low-dose aspirin as chemoprevention treatment in the average-risk population.

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References

  1. Lissa, D. Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. Proc. Natl Acad. Sci. USA 10.1073/pnas.1318440111

  2. Trabert, B. Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the ovarian cancer association consortium. J. Natl Cancer Inst. 10.1093/jnci/djt431

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Authors
  1. Alessia Errico
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Errico, A. Daily aspirin and chemoprevention. Nat Rev Clin Oncol 11, 180 (2014). https://doi.org/10.1038/nrclinonc.2014.35

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  • DOI: https://doi.org/10.1038/nrclinonc.2014.35

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