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Gynaecological cancer

ADAMTS mutations predict sensitivity to chemotherapy in ovarian cancer

Nature Reviews Clinical Oncology volume 12, page 504 (2015)Cite this article

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Ovarian cancer is the leading cause of mortality from gynaecological cancer; however, despite aggressive treatment most patients will develop disease progression owing to chemotherapy resistance. Now, a study led by Wei Zhang suggests that the presence of mutations in the ADAMTS genes renders tumours more sensitive to platinum-based therapy.

In general, 70% of patients with ovarian cancer respond well to chemotherapy; 20% of these cases are attributable to the presence of BRCA1/2 mutations—suggesting that other events might predict chemotherapy response, which remains highly unpredictable.

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References

  1. Liu, Y. et al. Association of somatic mutations of ADAMTS genes with chemotherapy sensitivity and survival in high-grade serous ovarian carcinoma. JAMA Oncol. 10.1001/jamaoncol.2015.1432

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Authors
  1. Alessia Errico
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Errico, A. ADAMTS mutations predict sensitivity to chemotherapy in ovarian cancer. Nat Rev Clin Oncol 12, 504 (2015). https://doi.org/10.1038/nrclinonc.2015.122

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